Ocular Surface Disease with BAK preserved Travoprost and Polyquaternium 1(Polyquad) preserved Travoprost
نویسندگان
چکیده
منابع مشابه
Ocular surface disease in patients with glaucoma or ocular hypertension treated with either BAK-preserved latanoprost or BAK-free travoprost
PURPOSE The preservative benzalkonium chloride (BAK) may adversely affect ocular surface health. This study evaluated symptoms of ocular surface disease (OSD) in patients previously treated with a BAK-preserved therapy to lower their intraocular pressure, who either continued that therapy or switched to a BAK-free therapy. METHODS Eligible adult patients with ocular hypertension or open-angle...
متن کاملEfficacy and tolerability of benzalkonium chloride-free travoprost in glaucoma patients switched from benzalkonium chloride-preserved latanoprost or bimatoprost
INTRODUCTION The preservative benzalkonium chloride (BAK) is used to preserve several topical, intraocular pressure (IOP)-lowering glaucoma medications but can cause tolerability concerns that may lead to decreased adherence to treatment and ultimately diminish the effectiveness of IOP control. The study aimed to determine the efficacy and tolerability of BAK-free travoprost preserved with poly...
متن کاملOcular surface safety of a new antiglaucoma BAK-free fixed combination of travoprost 0.004%/timolol 0.5% versus BAK-preserved travoprost 0.004%/timolol 0.5% and latanoprost 0.005%/timolol 0.5% ophthalmic solutions: an in vivo toxicity study
Purpose: Compared to the well-documented cytotoxic quaternary ammonium Benzalkonium chloride (BAK), Polyquaternium-1 (PQ) is proposed to be safer for the ocular surface. Using an established acute rabbit toxicological model, we tested the toxicological profiles of three topical antiglaucoma treatments: two commercially available fixed combinations of latanoprost/timolol containing 0.020% BAK (l...
متن کاملEffects of prostaglandin analog therapy on the ocular surface of glaucoma patients
PURPOSE To quantify changes in tear break-up time (TBUT), corneal staining and ocular surface disease index (OSDI) in glaucoma patients after switching therapy from latanoprost with 0.02% benzalkonium chloride (BAK) to travoprost with sofZia(). METHODS Prospective consecutive case series evaluating patients before and 8 weeks after switching from latanoprost with BAK to travoprost with sofZia...
متن کاملIn vitro studies of antiglaucomatous prostaglandin analogues: travoprost with and without benzalkonium chloride and preserved latanoprost.
PURPOSE With use of the Wong-Kilbourne derivative Chang conjunctival cell line, this study compared in vitro the ocular toxicity of three topical intraocular pressure (IOP)-lowering agents: travoprost 0.004% containing 0.015% benzalkonium chloride (BAK), travoprost Z 0.004%, a new formulation without BAK, and latanoprost 0.005% containing 0.02% BAK. METHODS Neutral red, Alamar blue, YOPRO-1, ...
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ژورنال
عنوان ژورنال: romanian journal of ophthalmology
سال: 2019
ISSN: 2457-4325,2501-2533
DOI: 10.22336/rjo.2019.38